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Analysis of Peripheral B Cell Subsets in Patients With Allergic Rhinitis
Allergy, Asthma & Immunology Research ; : 236-243, 2018.
Article in English | WPRIM | ID: wpr-714723
ABSTRACT

PURPOSE:

Recent evidence suggests that B cells can both promote and inhibit the development and progression of allergic disease. However, the characteristics of B cell subsets in patients with allergic rhinitis (AR) have not been well documented. This study aimed to analyze the characteristics of B cell subsets in the peripheral blood of AR patients.

METHODS:

Forty-seven AR patients and 54 healthy controls were enrolled in this study, and the B cell subsets in peripheral blood of all subjects were analyzed by flow cytometry. Moreover, the serum total immunoglobulin E (IgE) and IgE concentrations secreted into the cultured peripheral blood mononuclear cells (PBMCs) were measured by using enzyme-linked immunosorbent assay.

RESULTS:

We found the peripheral blood of AR patients contained higher percentages of memory B cells, plasma cells, and CD19+CD24hiCD27+ regulatory B cells (Bregs) than those of age-matched healthy controls (P < 0.05), while the percentages of naïve B cells and CD19+CD24hiCD38hi Bregs were significantly lower in AR patients than in healthy individuals (P < 0.05). In addition, the serum total IgE and IgE concentrations secreted into the cultured PBMCs were elevated in AR patients than in the healthy controls (P < 0.05).

CONCLUSIONS:

Our findings indicate that AR patients were characterized by increase in terminally differentiated memory B cells or plasma cells and decreases in CD19+CD24hiCD38hi Breg cells in the peripheral blood.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Plasma Cells / Immunoglobulin E / Immunoglobulins / Enzyme-Linked Immunosorbent Assay / B-Lymphocytes / B-Lymphocyte Subsets / B-Lymphocytes, Regulatory / Rhinitis, Allergic / Flow Cytometry / Memory Limits: Humans Language: English Journal: Allergy, Asthma & Immunology Research Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plasma Cells / Immunoglobulin E / Immunoglobulins / Enzyme-Linked Immunosorbent Assay / B-Lymphocytes / B-Lymphocyte Subsets / B-Lymphocytes, Regulatory / Rhinitis, Allergic / Flow Cytometry / Memory Limits: Humans Language: English Journal: Allergy, Asthma & Immunology Research Year: 2018 Type: Article