Association between Plasma Pentraxin 3 Levels and Bone Mineral Density in Elderly Koreans: the Dong-gu Study
Journal of Korean Medical Science
;
: e165-2018.
Article
in English
| WPRIM
| ID: wpr-714823
ABSTRACT
BACKGROUND:
We investigated the association between pentraxin 3 (PTX3), a novel inflammatory marker, and bone mineral density (BMD) in the general Korean population.METHODS:
We selected a sub-cohort of 1,440 subjects (757 men and 683 women) from participants in the community-based Dong-gu Study. The mean age was 66.0 ± 8.1 years for men and 63.7 ± 7.9 years for women. The plasma PTX3 levels were measured using an enzyme-linked immunosorbent assay, and BMD was measured in the femoral neck and lumbar spine using dual-energy X-ray absorptiometry. Linear regression analyses were used to evaluate the association between the plasma PTX3 levels and BMD.RESULTS:
PTX3 was inversely associated with the BMD of the lumbar spine (P = 0.010) and femoral neck (P < 0.001) in men but not in women. For men, the association with the BMD of the femoral neck remained after adjustment for multiple comparison (P = 0.020).CONCLUSION:
This study suggests that PTX3 levels might be inversely associated with BMD in elderly men.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Spine
/
Enzyme-Linked Immunosorbent Assay
/
Absorptiometry, Photon
/
Bone Density
/
Linear Models
/
Femur Neck
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS