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Fractionated Gamma Knife Radiosurgery as Initial Treatment for Large Skull Base Meningioma
Experimental Neurobiology ; : 245-255, 2018.
Article in English | WPRIM | ID: wpr-714903
ABSTRACT
We present our experience on the hypofractionated Gamma Knife radiosurgery (FGKS) for large skull base meningioma as an initial treatment. We retrospectively reviewed 23 patients with large skull base meningioma ≥10 cm³ who underwent FGKS as the initial treatment option. The mean volume of tumors prior to radiosurgery was 21.2±15.63 cm³ (range, 10.09~71.42). The median total margin dose and marginal dose per fraction were 18 Gy (range, 15~20) and 6 Gy (range, 5~6), respectively. Patients underwent three or four fractionations in consecutive days with the same Leksell® frame. The mean follow-up duration was 38 months (range, 17~78). There was no mortality. At the last follow-up, the tumor volume was stationary in 15 patients (65.2%) and had decreased in 8 patients (34.8%). Six patients who had cranial neuropathy at the time of FGKS showed improvement at the last clinical follow-up. Following FGKS, 4 patients (17%) had new cranial neuropathy. The trigeminal neuropathy was the most common and all were transient. The mean Karnofsky Performance Status score at pre-FGKS and the last clinical follow-up was 97.0±10.4 points (median, 100) and 98.6±6.9 (median, 100) points, respectively. FGKS has showed satisfactory tumor control with functional preservation for large skull base meningiomas. Further prospective studies of large cohorts with long term follow-up are required to clarify the efficacy in the tumor control and functional outcome as well as radiation toxicity.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Skull / Prospective Studies / Retrospective Studies / Cohort Studies / Follow-Up Studies / Mortality / Radiosurgery / Karnofsky Performance Status / Skull Base / Cranial Nerve Diseases Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: Experimental Neurobiology Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Skull / Prospective Studies / Retrospective Studies / Cohort Studies / Follow-Up Studies / Mortality / Radiosurgery / Karnofsky Performance Status / Skull Base / Cranial Nerve Diseases Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Humans Language: English Journal: Experimental Neurobiology Year: 2018 Type: Article