Sepsis and Meningitis due to Listeria Monocytogenes
Yonsei Medical Journal
;
: 433-439, 2007.
Article
in English
| WPRIM
| ID: wpr-71497
ABSTRACT
PURPOSE:
This study focused on the effect of immuno-compromising conditions on the clinical presentation of severe listerial infection. PATIENTS ANDMETHODS:
Nine human listeriosis cases seen from 1991-2002 were reviewed. All adult patients, from whose blood, peritoneal fluid or cerebrospinal fluid (CSF) the L. monocytogenes was isolated, were included in this retrospective study.RESULTS:
Listeriosis presented as primary sepsis with positive blood cultures in 5 cases and meningitis with positive CSF cultures in 4 cases. All of these patients had at least one underlying disease, most commonly, hematologic malignancy, diabetes mellitus, amyloidosis and hepatic cirrhosis; 55.6% had received immunosuppressive or corticosteroid therapy within a week before the onset of listeriosis. The patients were adults with a mean age of 60 years. Fever, night sweats, chills and lethargy were the most common symptoms; high temperature (> 38 degrees C), tachycardia, meningeal signs and poor conditions in general were the most common findings on admission. The mortality rate was 33.3% and was strictly associated with the severity of the underlying disease. Mortality differences were significant between sepsis (20%) and meningitis (50%) patients.CONCLUSION:
Listeriosis as an uncommon infection in our region and that immuno- suppressive therapy is an important pre-disposing factor of listeriosis. Sepsis and meningitis were more common in this group of patients and had the highest case-fatality rate for food-borne illnesses.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ascitic Fluid
/
Retrospective Studies
/
Treatment Outcome
/
Meningitis, Bacterial
/
Adrenal Cortex Hormones
/
Sepsis
/
Immunosuppressive Agents
/
Listeriosis
/
Listeria monocytogenes
Type of study:
Observational study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Yonsei Medical Journal
Year:
2007
Type:
Article
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