Effects of DA-5513 on alcohol metabolism and alcoholic fatty liver in rats / 한국실험동물학회지
Laboratory Animal Research
; : 49-57, 2018.
Article
in En
| WPRIM
| ID: wpr-715047
Responsible library:
WPRO
ABSTRACT
Hangover is characterized by a number of unpleasant physical and mental symptoms that occur after heavy alcohol drinking. In addition, consistently excessive alcohol intake is considered as a major reason causes liver disease. The present study investigated the in vivo effects of DA-5513 (Morning care® Kang Hwang) on biological parameters relevant to hangover relief and alcoholic fatty liver. Blood alcohol and acetaldehyde concentrations were determined in rats administered a single dose of alcohol and treated with DA-5513 or commercially available hangover relief beverages (Yeomyung® and Ukon®). The effects of DA-5513 on alcoholic fatty liver were also determined in rats fed alcohol-containing Lieber-DeCarli diets for 4 weeks. Serum liver function markers (aspartate and alanine aminotransferase activities) and serum/liver lipid levels were assessed. Blood alcohol and acetaldehyde concentrations were lower in the groups treated with DA-5513 or Yeomyung®, as compared with control rats. However, Ukon® did not produce any significant effects on these parameters. Treatment with DA-5513 significantly reduced serum aspartate and alanine aminotransferase activities and markedly reduced serum cholesterol and triglyceride levels, as compared with control rats. Histological observations using Oil Red O staining found that DA-5513 delayed the development of alcoholic fatty liver by reversing hepatic fat accumulation. These findings suggest that DA-5513 could have a beneficial effect on alcohol-induced hangovers and has the potential to ameliorate alcoholic fatty liver.
Key words
Full text:
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Index:
WPRIM
Main subject:
Triglycerides
/
Beverages
/
Alcohol Drinking
/
Cholesterol
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Aspartic Acid
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Diet
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Alanine Transaminase
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Fatty Liver, Alcoholic
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Alcoholics
/
Liver
Limits:
Animals
/
Humans
Language:
En
Journal:
Laboratory Animal Research
Year:
2018
Type:
Article