Multiple Markers of Contrast Induced Nephropathy after the Percutaneous Coronary Intervention
Soonchunhyang Medical Science
;
: 15-21, 2018.
Article
in English
| WPRIM
| ID: wpr-715119
ABSTRACT
OBJECTIVE:
Contrast-induced nephropathy (CIN) frequently occurs after percutaneous intervention. Objective of this study was to investigate the usefulness of serum cystatin C, neutrophil gelatinase-associated lipocalcin (NGAL), urinary kidney injury molecule-1 (KIM-1), and interleukin-18 (IL-18) as early predictors for CIN after percutaneous coronary intervention (PCI).METHODS:
In 53 patients who underwent PCI were enrolled. Serum creatinine and cystatin C level were measured immediately before, and 24 hours and 48 hours after catheterization. Serum NGAL, urinary KIM-1, and IL-18 were measured immediately before, and 4 hours, 24 hours, and 48 hours after catheterization. CIN was defined as a rise in creatinine 0.5 mg/dL or 25% above baseline.RESULTS:
CIN occurred in four patients (7.5%). Serum cystatin C levels were higher at 24 hours and 48 hours in CIN patients than in those without CIN (P<0.05). Serum NGAL levels were higher at 48 hours in CIN patients than in those without CIN. Urinary KIM-1 levels were higher at 48 hours in CIN patients than in those without CIN. There were no significant markers of CIN on multi-variate analysis.CONCLUSION:
In this study, the occurrence of CIN after PCI was 7.5%. Although there were some time-course changes in serum cystatin C and urinary KIM-1 after PCI, there was no significant predictor for CIN after PCI.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Catheterization
/
Contrast Media
/
Interleukin-18
/
Creatinine
/
Cystatin C
/
Catheters
/
Percutaneous Coronary Intervention
/
Kidney
/
Neutrophils
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Soonchunhyang Medical Science
Year:
2018
Type:
Article
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