Sequential evolution of IL-17 responses in the early period of allograft rejection
Experimental & Molecular Medicine
; : 707-716, 2009.
Article
in En
| WPRIM
| ID: wpr-71512
Responsible library:
WPRO
ABSTRACT
In addition to CD4+CD25+Foxp3+ regulatory T (T(reg)) cells which protect against autoimmune tissue injury, IL-17-producing CD4+ T (Th17) cells have been recently described and shown to play a crucial role in autoimmune injury. It appears that there is a reciprocal developmental pathway between Th17 and T(reg) cells. Although IL-17 is known to be associated with allograft rejection, the cellular source of IL-17 and the nature of Th17 in the context of allograft rejection remain unknown. In the current study, the dynamics of T(reg) and IL-17-producing cells after syngeneic and allogeneic transplantation were examined using a wild-type murine cardiac transplantation model. Ly6G+ cells were found to produce IL-17 during the early postoperative period and CD8+ as well as CD4+ T cells were also found to produce IL-17 during alloimmune response. Graft-infiltrating Ly6G+, CD4+, and even CD8+ cells were found to express IL-17 highly compared to those in spleen. Although the frequencies of Th17 and T(reg) were found to gradually increase in both syngeneic and allogeneic recipients, Th17/T(reg) ratios were significantly higher in recipients with allograft rejection than in syngeneic recipients. In conclusion, IL-17 is produced by neutrophils during the early postoperative period and subsequently by Th17 and CD8+ T cells during allograft rejection. Th17/T(reg) imbalance is associated with the development of allograft rejection. This study would provide basic information on Th17 biology for future investigation in the field of transplantation.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Time Factors
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Transplantation Immunology
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Antigens, CD
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Autoimmunity
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T-Lymphocyte Subsets
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Heart Transplantation
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T-Lymphocytes, Regulatory
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Interleukin-17
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Forkhead Transcription Factors
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Graft Rejection
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Experimental & Molecular Medicine
Year:
2009
Type:
Article