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A Concomitant Hemato-Oncologic Disorder of Patient with Down Syndrome
Soonchunhyang Medical Science ; : 1-7, 2018.
Article in Korean | WPRIM | ID: wpr-715121
ABSTRACT
A patient with Down syndrome has hematologic and oncologic disorders of medical complication. Down syndrome shows that characteristic hematologic and oncologic abnormalities and developments of disorders are different at ages. Many hematologic disorders were related to Down syndrome. There are diseases of red blood cells, white blood cell disorders, platelet and bleeding disorders, aplastic anemia, and transient myeloproliferative disease. Acute myeloid leukemia, acute lymphoblastic leukemia, and rarely solid tumors (Neuroblastoma, Wilm's tumor, Hodgkin's lymphoma) are also associated with Down syndrome. We checked clinical manifestations of each disorder and we should make standard hematologic index of different age groups. In addition, the relations between chromosome 21 and hemato-oncologic disorders should be found. We need to investigate potential therapeutic interventions that can improve quality of life and life expectancy in patients with Down syndrome.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Quality of Life / Blood Platelets / Chromosomes, Human, Pair 21 / Leukemia, Myeloid, Acute / Life Expectancy / Down Syndrome / Wilms Tumor / Erythrocytes / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Hemorrhage Limits: Humans Language: Korean Journal: Soonchunhyang Medical Science Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Quality of Life / Blood Platelets / Chromosomes, Human, Pair 21 / Leukemia, Myeloid, Acute / Life Expectancy / Down Syndrome / Wilms Tumor / Erythrocytes / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Hemorrhage Limits: Humans Language: Korean Journal: Soonchunhyang Medical Science Year: 2018 Type: Article