Increased arterial stiffness causing resistant hypertension in an adolescent with Neurofibromatosis type 1 / 고신대학교의과대학학술지
Kosin Medical Journal
;
: 105-109, 2018.
Article
in English
| WPRIM
| ID: wpr-715143
ABSTRACT
Neurofibromatosis type 1 is an autosomal dominant genetic disorder characterized by the presence of café au lait spots, axillary and inguinal freckling, Lisch nodules, and neurofibromas. Hypertension is a relatively frequent complication, usually caused by renal artery stenosis or pheochromocytomas. We describe the case of a 15-year-old boy with neurofibromatosis type 1 who was also diagnosed with resistant hypertension. Despite an extensive evaluation, the etiology of his hypertension remained indeterminate. Estimation of the brachial-ankle pulse wave velocity and ambulatory arterial stiffness index could validate the existence of arterial stiffness. Further, a combination of carvedilol and angiotension receptor blockers was administered, which successfully controlled his resistant hypertension. We propose that the estimation of the brachial-ankle pulse wave velocity measure and ambulatory arterial stiffness index is a noninvasive method, and these two parameters are relatively simple tools that can be used for the detection of arterial stiffness due to neurofibromatosis type 1-related vasculopathy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pheochromocytoma
/
Renal Artery Obstruction
/
Neurofibromatosis 1
/
Neurofibromatoses
/
Vascular Stiffness
/
Pulse Wave Analysis
/
Hypertension
/
Methods
/
Neurofibroma
Limits:
Adolescent
/
Humans
/
Male
Language:
English
Journal:
Kosin Medical Journal
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS