Ameliorative effects of Moringa on cuprizone-induced memory decline in rat model of multiple sclerosis / 대한해부학회지
Anatomy & Cell Biology
;
: 119-127, 2018.
Article
in English
| WPRIM
| ID: wpr-715224
ABSTRACT
Cuprizone is a neurotoxin with copper-chelating ability used in animal model of multiple sclerosis in which oxidative stress has been documented as one of the cascade in the pathogenesis. Moringa oleifera is a phytomedicinal plant with antioxidant and neuroprotective properties. This study aimed at evaluating the ameliorative capability of M. oleifera in cuprizone-induced behavioral and histopathological alterations in the prefrontal cortex and hippocampus of Wistar rats. Four groups of rats were treated with normal saline, cuprizone, M. oleifera and a combination of M. oleifera and cuprizone, for five weeks. The rats were subjected to Morris water maze and Y-maze to assess long and short-term memory respectively. The animals were sacrificed, and brain tissues were removed for histochemical and enzyme lysate immunosorbent assay for catalase, superoxide dismutase, and nitric oxide. Cuprizone significantly induced oxidative and nitrosative stress coupled with memory decline and cortico-hippocampal neuronal deficits; however, administration of M. oleifera significantly reversed the neuropathological deficits induced by cuprizone.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants
/
Superoxide Dismutase
/
Brain
/
Water
/
Catalase
/
Rats, Wistar
/
Prefrontal Cortex
/
Oxidative Stress
/
Cuprizone
/
Models, Animal
Limits:
Animals
Language:
English
Journal:
Anatomy & Cell Biology
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS