Evaluation of prooxidant-antioxidant balance in in vitro fertilization-conceived mice / 대한생식의학회지
Clinical and Experimental Reproductive Medicine
;
: 82-87, 2018.
Article
in English
| WPRIM
| ID: wpr-715308
ABSTRACT
OBJECTIVE:
Concerns about the safety of assisted reproductive technology (ART) have been raised, as some studies have shown elevated incidence rates of childhood cancer, asthma, allergies, and other diseases in ART-conceived babies. Findings regarding the health of ART-conceived babies are controversial. The present study was conducted to evaluate the prooxidant-antioxidant balance (PAB) in in vitro fertilization (IVF)-conceived mice in comparison to naturally conceived offspring.METHODS:
Mice (6–8 weeks) were divided into two groups (IVF-conceived and naturally conceived) matched by sex, age, weight, and litter size. A 1-mL blood sample was taken and the sera were separated. The oxidant-antioxidant balance was evaluated using a fast and reliable PAB assay. The results were expressed as mean±standard deviation.RESULTS:
The mean PAB values (HK units) in the IVF-conceived and naturally conceived groups were 59.70±22.30 and 54.70±18.22, respectively (p=0.82).CONCLUSION:
Since free radicals contribute to several pathological conditions and antioxidants play an important protective role against oxidative stress, evaluating the oxidant-antioxidant balance is very important. Although the results of this study showed that the quality of the defense mechanism against free radicals was not significantly different between the IVF-conceived and naturally conceived mice, other parameters of metabolic dysfunction need to be measured.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asthma
/
In Vitro Techniques
/
Fertilization in Vitro
/
Incidence
/
Oxidative Stress
/
Reproductive Techniques, Assisted
/
Free Radicals
/
Hypersensitivity
/
Litter Size
/
Antioxidants
Type of study:
Incidence study
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Clinical and Experimental Reproductive Medicine
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS