Pyrazinamide-Induced Urticaria and Angioedema: a Case Report / 대한내과학회지
Korean Journal of Medicine
;
: 306-310, 2018.
Article
in Korean
| WPRIM
| ID: wpr-715340
ABSTRACT
Pyrazinamide (PZA) is an anti-tuberculosis drug and an essential component of the standard four-drug regimen for tuberculosis. Here, we report a case of immediate angioedema secondary to PZA administration intended for pulmonary tuberculosis treatment. A previously healthy 48-year-old woman was diagnosed with pulmonary tuberculosis and tuberculous lymphadenitis. Thirty minutes after taking the first dose of isoniazid, rifampicin, pyrazinamide, and ethambutol, the patient developed facial edema, generalized rash, and dizziness. An oral provocation test was performed on the four drugs, and 1,000 mg pyrazinamide showed a positive result characterized by 50 minutes of urticaria, angioedema, and hypotension. As the prevalence of tuberculosis increases, prescriptions for anti-tuberculosis drugs may increase as well. Clinicians should be aware of the possibility of immediate hypersensitivity as well as delayed hypersensitivity to anti-tuberculosis drugs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pyrazinamide
/
Rifampin
/
Tuberculosis
/
Tuberculosis, Lymph Node
/
Tuberculosis, Pulmonary
/
Urticaria
/
Prevalence
/
Dizziness
/
Drug Hypersensitivity
/
Edema
Type of study:
Prevalence study
Limits:
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2018
Type:
Article
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