Variants in the Gene EBF2 Are Associated with Kawasaki Disease in a Korean Population
Yonsei Medical Journal
;
: 519-523, 2018.
Article
in English
| WPRIM
| ID: wpr-715389
ABSTRACT
PURPOSE:
Kawasaki disease (KD) is a mucocutaneous lymph node syndrome. It is mainly seen in young children under the age of five. KD is a multifactorial disorder that includes genetic variants. The present study investigated the association between KD and single nucleotide polymorphisms (SNPs) in the candidate gene early B cell factor 2 (EBF2), which is associated with inflammation markers. MATERIALS ANDMETHODS:
An SNP analysis was performed by whole exon sequencing of the EBF2 gene. Our study comprised a total of 495 subjects (295 KD patients and 200 unrelated normal controls) from a Korean population. Tag SNPs were discovered using the Haploview program. Genotyping of the EBF2 gene was performed with the TaqMan® assay with real-time PCR methods.RESULTS:
Polymorphism of rs10866845 showed a significant difference in allele frequency between KD patients and controls (p=0.040). The EBF2 gene polymorphisms were significantly associated with KD on logistic regression analysis.CONCLUSION:
EBF2 gene variants can contribute to KD in the Korean population.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Logistic Models
/
Exons
/
Polymorphism, Single Nucleotide
/
Real-Time Polymerase Chain Reaction
/
Gene Frequency
/
Inflammation
/
Mucocutaneous Lymph Node Syndrome
Type of study:
Prognostic study
/
Risk factors
Limits:
Child
/
Humans
Language:
English
Journal:
Yonsei Medical Journal
Year:
2018
Type:
Article
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