The Role of Helicobacter pylori Infection in Drug-induced Peptic Ulcer / 대한Helicobacter연구학회지
Korean Journal of Helicobacter and Upper Gastrointestinal Research
;
: 89-94, 2018.
Article
in Korean
| WPRIM
| ID: wpr-715426
ABSTRACT
Nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin (LDA) are the main causes of peptic ulcer (PU), and cause major complication such as bleeding and perforation. The interaction of Helicobacter pylori infection with NSAIDs or LDA is complex and remains unclear. However, H. pylori infection may play additive, synergistic, or antagonistic roles in the development of drug-induced PU. H. pylori infection and NSAID use are independent risk factors for the development of PU, which is thought to be a synergistic effect. Eradication of H. pylori significantly reduces the incidence of PU in NSAID-naïve patients. However, the effect of secondary prevention is controversial, especially in chronic NSAID users. The use of a gastroprotective agent such as a proton pump inhibitor (PPI) is mandatory to prevent the recurrence of PU in patients with a previous history, especially in chronic NSAID users. H. pylori infection may also increase the risk of LDA-associated complicated and uncomplicated PU, including the risk of upper gastrointestinal bleeding. In patients taking LDA, H. pylori eradication alone may prevent the recurrence of PU bleeding. However, PPI maintenance is necessary with concomitant use of an NSAID, steroid, anticoagulant, or other antiplatelet agents.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptic Ulcer
/
Recurrence
/
Platelet Aggregation Inhibitors
/
Anti-Inflammatory Agents, Non-Steroidal
/
Aspirin
/
Incidence
/
Risk Factors
/
Helicobacter pylori
/
Helicobacter
/
Proton Pumps
Type of study:
Etiology study
/
Incidence study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Helicobacter and Upper Gastrointestinal Research
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS