Role of Nonsteroidal Anti-inflammatory Drug in Treatment of Extra-abdominal Desmoid Tumors
Clinics in Orthopedic Surgery
;
: 225-233, 2018.
Article
in English
| WPRIM
| ID: wpr-715558
ABSTRACT
BACKGROUND:
We retrospectively reviewed the outcomes of patients who had been treated with meloxicam for the extra-abdominal desmoid tumors and evaluated the correlation between clinical outcome and clinic pathological variables.METHODS:
Twenty patients treated with meloxicam were followed up every 3 to 6 months. Meloxicam administration was planned at 15 mg/day orally for 6 months.RESULTS:
Of the 20 patients evaluated, according to Response Evaluation Criteria in Solid Tumors criteria, there were five patients with partial response (25.0%), eight with stable disease (40.0%), and seven with tumor progression (35.0%). The cumulative probability of dropping out from our nonsurgical strategy using meloxicam was 35.0% at 1 year and 35.0% at 5 years.CONCLUSIONS:
The present study suggests that conservative treatment would be a primary treatment option for this perplexing disease even though we were not able to determine that the use of a cyclooxygenase-2 inhibitor would have an additional influence on the natural course of a desmoid tumor.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Retrospective Studies
/
Fibromatosis, Aggressive
/
Cyclooxygenase 2
/
Response Evaluation Criteria in Solid Tumors
Type of study:
Observational study
Limits:
Humans
Language:
English
Journal:
Clinics in Orthopedic Surgery
Year:
2018
Type:
Article
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