Decreased IL-1ra and NCAM-1/CD56 Serum Levels in Unmedicated Patients with Schizophrenia Before and After Antipsychotic Treatment
Psychiatry Investigation
;
: 727-732, 2018.
Article
in English
| WPRIM
| ID: wpr-715598
ABSTRACT
OBJECTIVE:
Schizophrenia (SZ) has been associated with the inflammatory-related and immunological pathogenesis. This study investigates the aberration of cytokines in patients with SZ.METHODS:
Thirty patients with SZ without antipsychotic treatment for at least two weeks participated. We measured the serum levels of fourteen cytokines at hospital admission and after 8-week antipsychotic treatment. Severity was measured by expanded version of 24-items brief psychiatric rating scale (BPRS-E). Repeated measure analyses of variance were conducted.RESULTS:
The interleukin-1 receptor antagonist (IL-1ra) was significantly decreased after 8-week antipsychotic treatment than those of before antipsychotic treatment (F=12.15, df=1/30, p=0.002). Neural cell adhesion molecule 1/CD56 (NCAM-1/CD56) was significantly decreased (F=6.61, df=1/30, p=0.016) among those with second-generation antipsychotics but not first-generation antipsychotics treatment. The changes of BPRS-E-manic and BPRS-E-anxiety scores correlated with the baseline IL-1ra (r=-0.393), IL-6 (r=-0.407), and insulin like growth factor binding protein 3 (r=-0.446). Additionally, the changes of BPRS-E and BPRS-E-negative scores correlated with the changes of brain-derived neurotrophic factor (r=0.372) and interferon-gamma (r=0.375).CONCLUSION:
Our study supports that IL-1ra and NCAM-1/CD56 may be considered as markers of developing SZ.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Brief Psychiatric Rating Scale
/
Schizophrenia
/
Antipsychotic Agents
/
Carrier Proteins
/
Cytokines
/
Interleukin-6
/
Interferon-gamma
/
Interleukin-1
/
Neural Cell Adhesion Molecules
/
Brain-Derived Neurotrophic Factor
Limits:
Humans
Language:
English
Journal:
Psychiatry Investigation
Year:
2018
Type:
Article
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