Your browser doesn't support javascript.
loading
The Etiologies of Chronic Progressive Cerebellar Ataxia in a Korean Population
Journal of Clinical Neurology ; : 374-380, 2018.
Article in English | WPRIM | ID: wpr-715685
ABSTRACT
BACKGROUND AND

PURPOSE:

The etiologies and frequencies of cerebellar ataxias vary between countries. Our primary aim was to determine the frequency of each diagnostic group of cerebellar ataxia patients in a Korean population.

METHODS:

We reviewed the medical records of patients who were being followed up between November 1994 and February 2016. We divided patients with cerebellar ataxias into familial and non-familial groups and analyzed the frequency of each etiology. Finally, we categorized patients into genetic, sporadic, secondary, and suspected genetic, but undetermined ataxia.

RESULTS:

A total of 820 patients were included in the study, among whom 136 (16.6%) familial patients and 684 (83.4%) non-familial cases were identified. Genetic diagnoses confirmed 98/136 (72%) familial and 72/684 (11%) nonfamilial patients. The overall etiologies of progressive ataxias comprised 170 (20.7%) genetic, 516 (62.9%) sporadic, 43 (5.2%) secondary, and 91 (11.1%) undetermined ataxia. The most common cause of ataxia was multiple-system atrophy (57.3%). In the genetic group, the most common etiology was spinocerebellar ataxia (152/170, 89.4%) and the most common subtype was spinocerebellar ataxia-3.38 of 136 familial and 53 of 684 sporadic cases (91/820, 11.1%) were undetermined ataxia.

CONCLUSIONS:

This is the largest epidemiological study to analyze the frequencies of various cerebellar ataxias in a Korean population based on the large database of a tertiary hospital movement-disorders clinic in South Korea. These data would be helpful for clinicians in constructing diagnostic strategies and counseling for patients with cerebellar ataxias.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Ataxia / Atrophy / Friedreich Ataxia / Epidemiologic Studies / Cerebellar Ataxia / Medical Records / Counseling / Spinocerebellar Ataxias / Diagnosis / Tertiary Care Centers Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study Limits: Humans Country/Region as subject: Asia Language: English Journal: Journal of Clinical Neurology Year: 2018 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Ataxia / Atrophy / Friedreich Ataxia / Epidemiologic Studies / Cerebellar Ataxia / Medical Records / Counseling / Spinocerebellar Ataxias / Diagnosis / Tertiary Care Centers Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study Limits: Humans Country/Region as subject: Asia Language: English Journal: Journal of Clinical Neurology Year: 2018 Type: Article