Primary malignant melanoma of the uterine cervix treated with pembrolizumab after radical surgery: a case report and literature review
Obstetrics & Gynecology Science
;
: 524-528, 2018.
Article
in English
| WPRIM
| ID: wpr-715700
ABSTRACT
Malignant melanoma of the genital tract is a rare disease that is usually diagnosed by chance. When a definite diagnosis is delayed, the prognosis is very poor without standardized treatment. Herein, we describe a 40-year-old patient who presented with a history of bloody vaginal discharge for 7 months. Gynecological examination showed an exophytic, hard and pigmented cervical mass involving the upper vagina. The patient was diagnosed with cervical melanoma after a punch biopsy and underwent a radical hysterectomy, upper vaginectomy, bilateral salpingo-oophorectomy and pelvic lymphadenectomy. After surgeries, the patient underwent 2-cycles of adjuvant immunotherapy with pembrolizumab, but died within 8 months. In this report, treatment with pembrolizumab after radical surgery was not effective for this patient who had a primary cervical melanoma that metastasized to bone and lung tissue. We do not know why pembrolizumab was ineffective for this patient, but there are several possible explanations; further research is needed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Vagina
/
Biopsy
/
Uterine Cervical Neoplasms
/
Cervix Uteri
/
Vaginal Discharge
/
Rare Diseases
/
Diagnosis
/
Gynecological Examination
/
Antibodies, Monoclonal, Humanized
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Obstetrics & Gynecology Science
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS