14-bp Insertion/Deletion Polymorphism of the HLA-G Gene in Osteosarcoma Patients
Korean Journal of Pathology
;
: 485-490, 2011.
Article
in English
| WPRIM
| ID: wpr-71575
ABSTRACT
BACKGROUND:
The major histocompatibility complex class I, G (human leukocyte antigen-G [HLA-G]) gene plays a vital role in the suppression of immune responses. Recently, a number of studies have reported an association between HLA-G and diseases (pregnancy complications, organ transplantation, and tumors). Some of the studies have revealed that the 14-bp insertion/deletion polymorphism might be associated with various diseases. The aim of the present study was to explore a possible influence of the 14-bp insertion/deletion polymorphism on osteosarcoma.METHODS:
Genomic DNA was extracted from 75 formalin-fixed, paraffin-embedded tumor tissues derived from patients with conventional osteosarcoma (OSA) and 183 peripheral blood samples of healthy controls. Fifty-eight cases were South Korean patients with OSA and 17 cases were Argentine patients with OSA. The HLA-G 14-bp insertion/deletion polymorphism at exon 8 of the HLA-G locus was analyzed by polymerase chain reaction.RESULTS:
There was a significantly different distribution profile for the 14-bp genotypes between the Korean OSA and Korean control groups. Specifically, there were more heterozygote 210 bp/224 bp genotypes in the Korean OSA group when compared to the Korean control group (62.1% vs 40.4%, p=0.002).CONCLUSIONS:
The results suggest that HLA-G heterozygote patients may be more susceptible to OSA in the Korean population.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
DNA
/
Osteosarcoma
/
Exons
/
Organ Transplantation
/
Transplants
/
HLA-G Antigens
/
Genotype
/
Heterozygote
/
Leukocytes
/
Major Histocompatibility Complex
Limits:
Humans
Language:
English
Journal:
Korean Journal of Pathology
Year:
2011
Type:
Article
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