Expression of Hepatocyte Growth Factor/c-met by RT-PCR in Meningiomas
Korean Journal of Pathology
;
: 463-468, 2011.
Article
in English
| WPRIM
| ID: wpr-71578
ABSTRACT
BACKGROUND:
Hepatocyte growth factor (HGF) is a potent mitogenic cytokine. C-met protein, which is known to be the HGF receptor has transmembrane tyrosine kinase activity and is encoded by the c-met oncogene. The HGF/c-met signaling pathway may play various roles in the carcinogenesis of various organs.METHODS:
We examined HGF and c-met mRNA expression by utilizing reverse transcription polymerase chain reaction on 40 surgically resected intracranial meningiomas (25 benign, 10 atypical, and 5 anaplastic cases).RESULTS:
An HGF overexpression was detected in 28%, 50%, and 80% of the benign, atypical and anaplastic meningiomas, respectively; a high expression of HGF or the coexpression of HGF/c-met was detected in the high grade meningiomas (the atypical and anaplastic cases, p=0.046, p=0.014). An HGF expression was statistically significant in the recurrent meningiomas (p=0.003), and HGF expression was significantly lower than c-met mRNA expression in benign meningiomas (p=0.034).CONCLUSIONS:
There was no correlation between histologic subtypes and HGF/c-met expression. Determination of HGF expression can be used as a molecular predictor for recurrence of meningioimas. These results suggest that HGF and c-met expression in meningiomas may be associated with anaplastic progression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oncogenes
/
Recurrence
/
Protein-Tyrosine Kinases
/
RNA, Messenger
/
Polymerase Chain Reaction
/
Hepatocyte Growth Factor
/
Proto-Oncogene Proteins c-met
/
Hepatocytes
/
Reverse Transcription
/
Meningioma
Type of study:
Prognostic study
Language:
English
Journal:
Korean Journal of Pathology
Year:
2011
Type:
Article
Similar
MEDLINE
...
LILACS
LIS