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Serrated neoplasia pathway as an alternative route of colorectal cancer carcinogenesis
Intestinal Research ; : 358-365, 2018.
Article in English | WPRIM | ID: wpr-715885
ABSTRACT
In the past two decades, besides conventional adenoma pathway, a subset of colonic lesions, including hyperplastic polyps, sessile serrated adenoma/polyps, and traditional serrated adenomas have been suggested as precancerous lesions via the alternative serrated neoplasia pathway. Major molecular alterations of sessile serrated neoplasia include BRAF mutation, high CpG island methylator phenotype, and escape of cellular senescence and progression via methylation of tumor suppressor genes or mismatch repair genes. With increasing information of the morphologic and molecular features of serrated lesions, one major challenge is how to reflect this knowledge in clinical practice, such as pathologic and endoscopic diagnosis, and guidelines for treatment and surveillance.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phenotype / Polyps / United Nations / Colorectal Neoplasms / Adenoma / Genes, Tumor Suppressor / Cellular Senescence / Colon / CpG Islands / Diagnosis Type of study: Diagnostic study / Practice guideline Language: English Journal: Intestinal Research Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Phenotype / Polyps / United Nations / Colorectal Neoplasms / Adenoma / Genes, Tumor Suppressor / Cellular Senescence / Colon / CpG Islands / Diagnosis Type of study: Diagnostic study / Practice guideline Language: English Journal: Intestinal Research Year: 2018 Type: Article