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Clinical Risk Factors Influencing Dental Developmental Disturbances in Childhood Cancer Survivors / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment ; : 926-935, 2018.
Article in English | WPRIM | ID: wpr-715965
ABSTRACT

PURPOSE:

Although studies regarding dental developmental disturbances after childhood cancer treatment have increased, they have many limitations. Studies analyzing the significance of independent clinical risk factors with regard to the dental health status are also rare. We aimed to investigate the risk factors for dental developmental disturbances, particularly severe disturbances, in childhood cancer survivors (CCS). MATERIALS AND

METHODS:

Oral examinations and retrospective reviews of medical and panoramic radiographs were performed for 196 CCS (mean age, 15.6 years). Cancer type, age at diagnosis, treatment modality, type and accumulated dose of administered drugs, and dose and site of radiation were recorded. Dental developmental disturbances were diagnosed using panoramic radiographs and graded for severity according to the Modified Dental Defect Index (MDDI). Descriptive statistics and multivariate analyseswere performed to determine the association between dental abnormalities and clinical factors.

RESULTS:

In total, 109 CCS (55.6%) exhibited at least one dental anomaly, and the median value of MDDI was 2.5. Microdontia (30.6%) was the most prevalent anomaly, followed by tooth agenesis (20.4%), V-shaped roots (14.8%), and taurodontism (10.2%). Multivariate analysis revealed that a young age at diagnosis (≤ 3 years), a history of hematopoietic stem cell transplantation, the use of multiple classes of chemotherapeutic agents (≥ 4 classes), and the use of heavy metal agents were significant risk factors for severe dental disturbances.

CONCLUSION:

CCS with any of the above risk factors for severe developmental disturbances should be comprehensively followed up to minimize adverse consequences to their dental development and preserve their future dental health.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Tooth / Tooth Abnormalities / Multivariate Analysis / Retrospective Studies / Risk Factors / Survivors / Hematopoietic Stem Cell Transplantation / Diagnosis / Diagnosis, Oral / Odontogenesis Type of study: Diagnostic study / Etiology study / Observational study / Risk factors Limits: Humans Language: English Journal: Cancer Research and Treatment Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Tooth / Tooth Abnormalities / Multivariate Analysis / Retrospective Studies / Risk Factors / Survivors / Hematopoietic Stem Cell Transplantation / Diagnosis / Diagnosis, Oral / Odontogenesis Type of study: Diagnostic study / Etiology study / Observational study / Risk factors Limits: Humans Language: English Journal: Cancer Research and Treatment Year: 2018 Type: Article