Immunohistochemical Expression of PD-L1 in Cutaneous Squamous Cell Carcinoma and Its Association with Risk of Metastasis / 대한피부과학회지
Korean Journal of Dermatology
;
: 415-420, 2018.
Article
in Korean
| WPRIM
| ID: wpr-716125
ABSTRACT
BACKGROUND:
Programmed cell death ligand 1 (PD-L1) plays a major role in the immune responses of a variety of cancers. Recently, several studies revealed that PD-L1 is differently expressed in some cases of non-melanoma skin cancer. The expression of PD-L1 in cutaneous squamous cell carcinoma has not yet been described in Korea.OBJECTIVE:
To investigate the expression of PD-L1 in cutaneous squamous cell carcinoma and its association with variable clinicopathological factors.METHODS:
We performed immunohistochemical staining of 52 cutaneous cell carcinoma cases, including 28 high-risk cases and 24 low-risk cases. Cases were selected from patients who had visited the department of dermatology of our hospital from 2001 to 2017. The expression patterns were assessed using the H-score. Cases demonstrating at least 1+ of PD-L1 in more than 1% of tumor cells were considered positive.RESULTS:
PD-L1 expression of tumor cells was 19.2% (10/52) for all cases, 0.0% (0/24) for the low-risk group, and 35.7% (10/28) for the high-risk group. PD-L1 positive cutaneous squamous cell carcinoma cases showed a significantly higher proportion of large tumors and tumors with deep invasion and a higher lymphatic metastasis rate when compared to PD-L1 negative cutaneous squamous cell carcinoma cases.CONCLUSION:
Our study shows that cutaneous squamous cell carcinoma exhibits PD-L1 expression in 19.2% of cases. PD-L1 positive tumors are associated with high-risk cases of cutaneous squamous cell carcinoma, which may help guide the choice of therapeutic strategy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin Neoplasms
/
Carcinoma, Squamous Cell
/
Cell Death
/
Dermatology
/
Epithelial Cells
/
Korea
/
Lymphatic Metastasis
/
Neoplasm Metastasis
Type of study:
Etiology study
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS