Hippocampal Atrophy and Psychotic Symptoms in Patients with Alzheimer's Disease / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 261-265, 2018.
Article
in Korean
| WPRIM
| ID: wpr-716135
ABSTRACT
OBJECTIVES:
This study examined the difference in the volume or thickness of the medial temporal lobe between Alzheimer's disease patients with psychosis (AD+P) and those without psychosis (AD−P).METHODS:
Overall, 31 AD+P patients and 29 AD−P patients were included from the Memory impairment clinics of Pusan National University Hospital in Korea. AD+P was diagnosed according to Jeste and Finkel's proposed diagnostic criteria for psychosis of Alzheimer's disease. AD−P included AD patients with no psychotic symptoms during a 5-year follow-up period. Medial temporal volume or thickness was measured by 3-tesla MRI and freesufer analysis. Analysis of variance was used to examine the difference in the volume or thickness of medial temporal lobe between AP+P and AD−P after controlling for age, gender, education years, Clinical Dementia Rating scale-Sum of Box, and total intracranial volume.RESULTS:
The hippocampal volume in AD+P was smaller than that in AD−P.CONCLUSION:
These findings suggest that AD+P is associated with a reduced hippocampal volume.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Psychotic Disorders
/
Atrophy
/
Temporal Lobe
/
Magnetic Resonance Imaging
/
Follow-Up Studies
/
Dementia
/
Education
/
Alzheimer Disease
/
Hippocampus
/
Korea
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Journal of Korean Neuropsychiatric Association
Year:
2018
Type:
Article
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