Diagnosing Diabetic Neuropathy: Something Old, Something New
Diabetes & Metabolism Journal
;
: 255-269, 2018.
Article
in English
| WPRIM
| ID: wpr-716235
ABSTRACT
There are potentially many ways of assessing diabetic peripheral neuropathy (DPN). However, they do not fulfill U.S. Food and Drug Administration (FDA) requirements in relation to their capacity to assess therapeutic benefit in clinical trials of DPN. Over the past several decades symptoms and signs, quantitative sensory and electrodiagnostic testing have been strongly endorsed, but have consistently failed as surrogate end points in clinical trials. Therefore, there is an unmet need for reliable biomarkers to capture the onset and progression and to facilitate drug discovery in DPN. Corneal confocal microscopy (CCM) is a non-invasive ophthalmic imaging modality for in vivo evaluation of sensory C-fibers. An increasing body of evidence from multiple centers worldwide suggests that CCM fulfills the FDA criteria as a surrogate endpoint of DPN.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
United States Food and Drug Administration
/
Biomarkers
/
Peripheral Nervous System Diseases
/
Microscopy, Confocal
/
Diabetic Neuropathies
/
Diagnosis
/
Drug Discovery
Type of study:
Diagnostic study
Language:
English
Journal:
Diabetes & Metabolism Journal
Year:
2018
Type:
Article
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