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Effect of isoflavone-enriched whole soy milk powder supplementation on bone metabolism in ovariectomized mice
Nutrition Research and Practice ; : 275-282, 2018.
Article in English | WPRIM | ID: wpr-716444
ABSTRACT
BACKGROUND/

OBJECTIVE:

There is intense interest in soy isoflavone as a hormone replacement therapy for the prevention of postmenopausal osteoporosis. A new kind of isoflavone-enriched whole soy milk powder (I-WSM) containing more isoflavones than conventional whole soy milk powder was recently developed. The aim of this study was to investigate the effects of I-WSM on bone metabolism in ovariectomized mice. MATERIALS/

METHODS:

Sixty female ICR mice individually underwent ovariectomy (OVX) or a sham operation, and were randomized into six groups of 10 animals each as follows Sham, OVX, OVX with 2% I-WSM diet, OVX with 10% I-WSM diet, OVX with 20% I-WSM diet, and OVX with 20% WSM diet. After an 8-week treatment period, bone mineral density (BMD), calcium, alkaline phosphatase (ALP), tartrate-resistant acid phosphatase (TRAP) 5b, osteocalcin (OC), procollagen 1 N-terminal propeptide (P1NP), and osteoprotegenin (OPG) were analyzed.

RESULTS:

BMD was significantly lower in the OVX group compared to the Sham group but was significantly higher in OVX + 10% I-WSM and OVX + 20% I-WSM groups compared to the OVX group (P < 0.05). Serum calcium concentration significantly increased in the OVX + 10% and 20% I-WSM groups. Serum ALP levels were significantly lower in the OVX + 10% and 20% I-WSM groups compared to the other experimental groups (P < 0.05). OC was significantly reduced in the OVX group compared to the Sham group (P < 0.05), but a dose-dependent increase was observed in the OVX groups supplemented with I-WSM. P1NP and OPG levels were significantly reduced, while TRAP 5b level was significantly elevated in the OVX group compared with the Sham group, which was not affected by I-WSM (P < 0.05).

CONCLUSIONS:

This study suggests that I-WSM supplementation in OVX mice has the effect of preventing BMD reduction and promoting bone formation. Therefore, I-WSM can be used as an effective alternative to postmenopausal osteoporosis prevention.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteogenesis / Soybeans / Acid Phosphatase / Ovariectomy / Bone Density / Osteocalcin / Osteoporosis, Postmenopausal / Calcium / Procollagen / Bone Remodeling Type of study: Controlled clinical trial Limits: Animals / Female / Humans Language: English Journal: Nutrition Research and Practice Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteogenesis / Soybeans / Acid Phosphatase / Ovariectomy / Bone Density / Osteocalcin / Osteoporosis, Postmenopausal / Calcium / Procollagen / Bone Remodeling Type of study: Controlled clinical trial Limits: Animals / Female / Humans Language: English Journal: Nutrition Research and Practice Year: 2018 Type: Article