Functional Characterization of the Major Outer Membrane Protein ( MspTL ) of Treponema lecithinolyticum
Journal of Bacteriology and Virology
;
: 47-54, 2002.
Article
in Korean
| WPRIM
| ID: wpr-71647
ABSTRACT
Treponema lecithinolyticum is known to be associated with rapidly progressive periodontitis. The full-length gene encoding the major surface protein MspTL of this organism was cloned and expressed by using the expression vector pQE30. Recombinant Msp TL (rMsp TL) protein was purified and functionally characterized. Msp TL was one of several T. lecithinolyticum surface proteins that bound to cultured human gingival fibroblasts (HGFs). As well, it strongly induced IL-6 production by HGFs. These observations suggest that MspTL contributes to pathogenesis of periodontitis by adhesion to host cells and by induction of the proinflammatory cytokine IL-6.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Periodontitis
/
Treponema
/
Interleukin-6
/
Clone Cells
/
Fibroblasts
/
Membrane Proteins
/
Membranes
Limits:
Humans
Language:
Korean
Journal:
Journal of Bacteriology and Virology
Year:
2002
Type:
Article
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