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Linkage of Fibroblast Growth Factor 23 and Phosphate in Serum: Phosphate and Fibroblast Growth Factor 23 Reduction by Increasing Dose of Sevelamer
Journal of Bone Metabolism ; : 153-159, 2018.
Article in English | WPRIM | ID: wpr-716571
ABSTRACT

BACKGROUND:

High serum phosphate and fibroblast growth factor-23 (FGF-23) levels are well-recognized independent risk factors of mortality and morbidity in patients with chronic kidney diseases (CKDs). Sevelamer, as a phosphate chelating agent, reduces serum phosphate and FGF-23 levels produced by bone osteocytes. This study aimed to determine the best dose at which sevelamer could successfully reduce serum phosphate and FGF-23 levels in rat models of adenine-induced CKD.

METHODS:

CKD was induced using adenine. Healthy and CKD-induced rats were divided into 6 groups as follows healthy controls; CKD controls; rats treated with 1%, 2%, and 3% sevelamer for CKDs; and healthy rats administered 3% sevelamer. Biochemical factors and serum FGF-23 levels were measured using spectrophotometry and enzyme-linked immunosorbent assay methods.

RESULTS:

Serum phosphate levels were best decreased in rats receiving 3% sevelamer in their diet (5.91±1.48 mg/dL vs. 8.09±1.70 mg/dL, P < 0.05) compared with the CKD control rats. A dose-dependent decrease in serum FGF-23 levels was observed, and the most significant results were obtained in rats receiving 3% sevelamer compared with the CKD control rats (142.60±83.95 pg/mL vs. 297.15±131.10 pg/mL, P < 0.01).

CONCLUSIONS:

Higher sevelamer doses significantly reduced serum phosphate and FGF-23 levels in adenine-induced CKD rats.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteocytes / Phosphates / Spectrophotometry / Enzyme-Linked Immunosorbent Assay / Adenine / Risk Factors / Mortality / Models, Animal / Diet / Renal Insufficiency Type of study: Etiology study / Prognostic study / Risk factors Limits: Animals / Humans Language: English Journal: Journal of Bone Metabolism Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteocytes / Phosphates / Spectrophotometry / Enzyme-Linked Immunosorbent Assay / Adenine / Risk Factors / Mortality / Models, Animal / Diet / Renal Insufficiency Type of study: Etiology study / Prognostic study / Risk factors Limits: Animals / Humans Language: English Journal: Journal of Bone Metabolism Year: 2018 Type: Article