The Impact of Preoperative Low Body Mass Index on Postoperative Complications and Long-term Survival Outcomes in Gastric Cancer Patients
Journal of Gastric Cancer
;
: 274-286, 2018.
Article
in English
| WPRIM
| ID: wpr-716707
ABSTRACT
PURPOSE:
The aim of this study was to investigate the impact of preoperative low body mass index (BMI) on both the short- and long-term outcomes in patients with gastric cancer. MATERIALS ANDMETHODS:
A total of 510 patients with gastric cancer were divided into the following 3 groups low BMI group (≤18.5 kg/m2, n=51), normal BMI group (18.6–24.9 kg/m2, n=308), and high BMI group (≥25.0 kg/m2, n=151).RESULTS:
There were significantly more stage III/IV patients in the low BMI group than in the other groups (P=0.001). Severe postoperative complications were more frequent (P=0.010) and the survival was worse (P < 0.001) in the low BMI group. The subgroup analysis indicated that survival was worse in the low BMI group of the stage I/II subgroup (P=0.008). The severe postoperative complication rate was higher in the low BMI group of the stage III/IV subgroup (P=0.001), although the recurrence rate and survival did not differ in the stage III/IV subgroup among all the BMI groups. Low BMI was an independent poor prognostic factor in the stage I/II subgroup (disease-free survival hazard ratio [HR], 13.521; 95% confidence interval [CI], 1.186–154.197; P=0.036 and overall survival HR, 5.130; 95% CI, 1.644–16.010; P=0.005), whereas low BMI was an independent risk factor for severe postoperative complications in the stage III/IV subgroup (HR, 17.158; 95% CI, 1.383–212.940; P=0.027).CONCLUSIONS:
Preoperative low BMI in patients with gastric cancer adversely affects survival among those with stage I/II disease and increases the severe postoperative complication rate among those with stage III/IV disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Postoperative Complications
/
Recurrence
/
Stomach Neoplasms
/
Thinness
/
Body Mass Index
/
Risk Factors
/
Obesity
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Journal of Gastric Cancer
Year:
2018
Type:
Article
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