Factors affecting height velocity in normal prepubertal children
Annals of Pediatric Endocrinology & Metabolism
;
: 148-153, 2018.
Article
in English
| WPRIM
| ID: wpr-716848
ABSTRACT
PURPOSE:
To analyze the effects of clinical and laboratory factors, including insulin-like growth factor (IGF) levels, on the height velocity of normal prepubertal children.METHODS:
Ninety-five healthy prepubertal children (33 boys, 62 girls) were enrolled. The mean chronological age was 6.3±1.4 years, with a height standard deviation score (SDS) of -0.88±0.70. IGF-1, IGF binding protein-3 (IGFBP-3), SDS for anthropometric measurements, and changes in SDS for anthropometric measurements were analyzed for 1 year, and their associations with 1-year height velocity were investigated.RESULTS:
The group of children with a 1-year height velocity of ≥6 cm were chronologically younger than the group with a 1-year height velocity of < 6 cm (5.9±1.3 years vs. 6.7±1.3 years, P=0.004), with a lesser increase of SDS for body mass index (BMI) over 1 year (-0.18±0.68 vs. 0.13±0.53, P=0.014). There were no differences between the 2 groups in IGF-1 SDS and IGFBP-3 SDS. Multiple linear regression showed that baseline chronological age (r=0.243, P=0.026) and height SDS (r=0.236, P=0.030) were positively associated with IGF-1 SDS. Binomial logistic regression showed that an older chronologic age at referral (odds ratio [OR], 0.68; 95% confidence interval [CI], 0.47–0.99) and an increase of BMI SDS over 1 year (OR, 0.41; 95% CI, 0.18–0.89) were associated with a decreased growth possibility of an above-average height velocity (≥6 cm/yr).CONCLUSIONS:
Height velocity of normal prepubertal children is affected by an increase of BMI SDS and chronological age. Prepubertal IGF-1 SDS reflects height SDS at the time of measurement but is not associated with subsequent height velocity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Referral and Consultation
/
Insulin-Like Growth Factor I
/
Body Mass Index
/
Linear Models
/
Logistic Models
/
Insulin-Like Growth Factor Binding Protein 3
Type of study:
Prognostic study
/
Risk factors
Limits:
Child
/
Humans
Language:
English
Journal:
Annals of Pediatric Endocrinology & Metabolism
Year:
2018
Type:
Article
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