Evaluation of bone mineral status in prepuberal children with newly diagnosed type 1 diabetes
Annals of Pediatric Endocrinology & Metabolism
;
: 136-140, 2018.
Article
in English
| WPRIM
| ID: wpr-716850
ABSTRACT
PURPOSE:
Many studies have reported that patients with type 1 diabetes have reduced bone mineral density (BMD). We assessed bone status in prepubertal children with type 1 diabetes mellitus (type 1 DM) at initial diagnosis and investigated factors associated with BMD.METHODS:
Prepubertal children (n=29) with newly diagnosed type 1 diabetes from 2006 to 2014 were included. Dual-energy X-ray absorptiometry measured regional and whole-body composition at initial diagnosis. BMD was compared with healthy controls matched for age, sex, and body mass index (BMI).RESULTS:
The mean age of all subjects (16 boys and 13 girls) was 7.58±1.36 years (range, 4.8–11.3 years). Initial mean glycosylated hemoglobin (HbA1c) level was 12.2%±1.9%. The mean BMD z-scores of lumbar spine, femur neck, and total body were not significantly different between patients and controls. Three patients (10.3%) had low bone density (total body BMD standard deviation score [SDS] < -2.0). To identify determinants of lumbar spine BMD z-score, multivariate regression analysis was performed with stepwise variable selection of age, pubertal status, BMI SDS, insulin like growth factor-1, and HbA1c. Only BMI SDS was significantly correlated with lumbar spine BMD z-score (β=0.395, P=0.023).CONCLUSIONS:
Prepubertal children with newly diagnosed type 1 DM had similar bone mass compared to healthy peers. However, patients with low BMI should be carefully monitored for bone density in type 1 DM.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spine
/
Glycated Hemoglobin
/
Absorptiometry, Photon
/
Body Mass Index
/
Bone Density
/
Diabetes Mellitus, Type 1
/
Diagnosis
/
Femur Neck
/
Miners
/
Insulin
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Child
/
Humans
Language:
English
Journal:
Annals of Pediatric Endocrinology & Metabolism
Year:
2018
Type:
Article
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