Calpain-10 and Adiponectin Gene Polymorphisms in Korean Type 2 Diabetes Patients
Endocrinology and Metabolism
;
: 364-371, 2018.
Article
in English
| WPRIM
| ID: wpr-716968
ABSTRACT
BACKGROUND:
Genetic variations in calpain-10 and adiponectin gene are known to influence insulin secretion and resistance in type 2 diabetes mellitus. Recently, several single nucleotide polymorphisms (SNPs) in calpain-10 and adiponectin gene have been reported to be associated with type 2 diabetes and various metabolic derangements. We investigated the associations between specific calpain-10 and adiponectin gene polymorphisms and Korean type 2 diabetes patients.METHODS:
Overall, 249 type 2 diabetes patients and 131 non-diabetic control subjects were enrolled in this study. All the subjects were genotyped for SNP-43 and -63 of calpain-10 gene and G276T and T45G frequencies of the adiponectin gene. The clinical characteristics and measure of glucose metabolism were compared within these genotypes.RESULTS:
Among calpain-10 polymorphisms, SNP-63 T/T were more frequent in diabetes patients, and single SNP-63 increases the susceptibility to type 2 diabetes. However, SNP-43 in calpain-10 and T45G and intron G276T in adiponectin gene were not significantly associated with diabetes, insulin resistance, nor insulin secretion.CONCLUSION:
Variations in calpain-10, SNP-63 seems to increase the susceptibility to type 2 diabetes in Koreans while SNP-43 and adiponectin SNP-45, -276 are not associated with impaired glucose metabolism.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Genetic Variation
/
Insulin Resistance
/
Introns
/
Polymorphism, Single Nucleotide
/
Diabetes Mellitus, Type 2
/
Adiponectin
/
Genotype
/
Glucose
/
Insulin
/
Metabolism
Limits:
Humans
Language:
English
Journal:
Endocrinology and Metabolism
Year:
2018
Type:
Article
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