Successful Salvage Unrelated Umbilical Cord Blood Transplantation with Two Units After Engraftment Failure with Single Unit in Severe Aplastic Anemia
Journal of Korean Medical Science
;
: 744-746, 2009.
Article
in English
| WPRIM
| ID: wpr-71710
ABSTRACT
Severe aplastic anemia (SAA) patients without an HLA-matched sibling donor need alternative treatment options. Umbilical cord blood transplantation (UCBT) has become an alternative means for treating various diseases, but it has not been proved to be a satisfactory method to treat SAA. Here, we report the case of a girl who underwent successful two-unit UCBT after engraftment failure with a single unit. Twounit UCBT is proposed to have better engraftment potential and to offer a better chance of survival, according to some reports. Increased cell dose and graft-versus-graft reaction could contribute to these advantages. With this promising result, two-unit UCBT could be an alternative treatment option for patients with SAA without an HLA-matched donor.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
In Situ Hybridization, Fluorescence
/
Cord Blood Stem Cell Transplantation
/
Graft vs Host Disease
/
Histocompatibility
/
HLA Antigens
/
Anemia, Aplastic
Limits:
Child, preschool
/
Female
/
Humans
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2009
Type:
Article
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