Anti-phospholipase A2 receptor antibody as a prognostic marker in patients with primary membranous nephropathy
Kidney Research and Clinical Practice
;
: 248-256, 2018.
Article
in English
| WPRIM
| ID: wpr-717214
ABSTRACT
BACKGROUND:
Phospholipase A2 receptor (PLA2R) has been identified as a major autoantigen in primary membranous nephropathy (MN). We evaluated the association between anti-PLA2R antibodies and clinical outcome in Korean patients with primary MN.METHODS:
A total of 66 patients with biopsy-proven MN were included. Serum level of anti-PLA2R antibodies was measured by enzyme-linked immunosorbent assay. Biochemical parameters were estimated initially and at follow-up.RESULTS:
Anti-PLA2R antibodies were detected in 52.1% and 27.8% of patients with primary and secondary MN, respectively. Forty-eight patients with primary MN were grouped based on presence or absence of anti-PLA2R antibodies. Proteinuria was more severe in anti-PLA2R-positive patients than in anti-PLA2R-negative patients (urine protein/creatinine ratio 7.922 ± 3.985 g/g vs. 4.318 ± 3.304 g/g, P = 0.001), and anti-PLA2R antibody level was positively correlated with proteinuria. The incidence of chronic kidney disease stage ≥ 3 was higher in anti-PLA2R-positive patients compared with anti-PLA2R-negative patients (P = 0.004). The probabilities of spontaneous remission were higher in anti-PLA2R-negative patients compared with anti-PLA2R-positive patients (P < 0.001). Multivariate analysis demonstrated that anti-PLA2R antibodies are an independent risk factor for developing chronic kidney disease stage ≥ 3 and for not reaching spontaneous remission.CONCLUSION:
Detection of anti-PLA2R antibodies at diagnosis in patients with primary MN can predict prognosis and guide treatment decisions.
Full text:
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Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Proteinuria
/
Remission, Spontaneous
/
Enzyme-Linked Immunosorbent Assay
/
Glomerulonephritis, Membranous
/
Incidence
/
Multivariate Analysis
/
Risk Factors
/
Follow-Up Studies
/
Diagnosis
Type of study:
Diagnostic study
/
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Kidney Research and Clinical Practice
Year:
2018
Type:
Article
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