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Stem cell transplantation and functional recovery after spinal cord injury: a systematic review and meta-analysis / 대한해부학회지
Anatomy & Cell Biology ; : 180-188, 2018.
Article in English | WPRIM | ID: wpr-717224
ABSTRACT
Spinal cord injury is a significant cause of motor dysfunctions. There is no definite cure for it, and most of the therapeutic modalities are only symptomatic treatment. In this systematic review and meta-analysis, the effectiveness of stem cell therapy in the treatment of the spinal cord injuries in animal models was studied and evaluated. A systematic search through medical databases by using appropriate keywords was conducted. The relevant reports were reviewed in order to find out cases in which inclusion and exclusion criteria had been fulfilled. Finally, 89 articles have been considered, from which 28 had sufficient data for performing statistical analyses. The findings showed a significant improvement in motor functions after cell therapy. The outcome was strongly related to the number of transplanted cells, site of injury, chronicity of the injury, type of the damage, and the induction of immune-suppression. According to our data, improvements in functional recovery after stem cell therapy in the treatment of spinal cord injury in animal models was noticeable, but its outcome is strongly related to the site of injury, number of transplanted cells, and type of transplanted cells.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Spinal Cord / Spinal Cord Injuries / Stem Cells / Contusions / Models, Animal / Stem Cell Transplantation / Cell- and Tissue-Based Therapy Type of study: Prognostic study / Systematic reviews Language: English Journal: Anatomy & Cell Biology Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Spinal Cord / Spinal Cord Injuries / Stem Cells / Contusions / Models, Animal / Stem Cell Transplantation / Cell- and Tissue-Based Therapy Type of study: Prognostic study / Systematic reviews Language: English Journal: Anatomy & Cell Biology Year: 2018 Type: Article