Abnormal Oculomotor Functions in Amyotrophic Lateral Sclerosis
Journal of Clinical Neurology
;
: 464-471, 2018.
Article
in English
| WPRIM
| ID: wpr-717429
ABSTRACT
BACKGROUND AND PURPOSE:
Although traditionally regarded as spared, a range of oculomotor dysfunction has been recognized in amyotrophic lateral sclerosis (ALS) patients. ALS is nowadays considered as a neurodegenerative disorder of a third compartment comprising widespread areas of extra-motor brain including cerebellum. Our objective was to perform an observational study to examine for ocular motor dysfunction in patients with ALS and for any differences between bulbar-onset and spinal-onset patients.METHODS:
Thirty two ALS patients (bulbar onset 10, spinal onset 22) underwent the standardized systemic evaluations using video-oculography.RESULTS:
Oculomotor dysfunctions such as square wave jerks, saccadic dysmetria, abnormal cogwheeling smooth pursuits and head shaking and positional nystagmus of central origin have been observed in the ALS patients at a relatively early stage. Abnormal smooth pursuits and saccadic dysmetria were increased in the bulbar-onset compared to the spinal-onset (p < 0.05).CONCLUSIONS:
These oculomotor abnormalities may be a marker of neuro-degeneration beyond motor neurons in ALS, especially in bulbar-onset disease. Future longitudinal studies of eye movement abnormalities have provided insights into the distribution and nature of the disease process.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pursuit, Smooth
/
Brain
/
Nystagmus, Physiologic
/
Cerebellar Ataxia
/
Cerebellum
/
Longitudinal Studies
/
Neurodegenerative Diseases
/
Eye Movements
/
Observational Study
/
Head
Type of study:
Observational study
Limits:
Humans
Language:
English
Journal:
Journal of Clinical Neurology
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS