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Thromboembolic Events as Prognostic Clinical Markers in Advanced Pancreatic and Biliary Tract Cancer / 대한내과학회지
Korean Journal of Medicine ; : 457-463, 2018.
Article in Ko | WPRIM | ID: wpr-717450
Responsible library: WPRO
ABSTRACT
BACKGROUND/AIMS: Venous thromboembolic events (VTEs) are common events in patients with advanced cancer. We analyzed the clinical characteristics of VTEs in advanced pancreatic and biliary tract cancer to determine the clinical significance, especially in palliative settings. METHODS: Seventy-nine patients with advanced pancreatic cancer or biliary tract cancer who had thromboembolic events were retrospectively reviewed. We investigated the correlation between clinical course and thromboembolic events, and the laboratory risk factors, such as complete blood count profile. RESULTS: The 79 patients consisted of 40 men (50.6%) and 39 women (49.4%) with a median age of 65 years old (range: 41–80). Forty-three patients (54.4%), had thromboembolic events without any symptoms. Pulmonary thromboembolism occurred in only 31 cases (39.2%), and combined thrombosis at more than two sites occurred in 17 cases (21.5%). Of the 51 patients with active chemotherapy, 45 showed progressive disease. The median survival times were 11.9 weeks in all patients, 15.3 weeks in the treatment group, and 3.4 weeks in the palliative group. There was no difference in survival time between patients treated with dalteparin only and those treated with dalteparin combined with thrombolytic intervention. CONCLUSIONS: VTE can be poor prognostic indicator in pancreatic and biliary tract cacner patients, suggestive of progressive disease and a sign of short life expectancy, requiring hospice and terminal care.
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Full text: 1 Index: WPRIM Main subject: Pancreatic Neoplasms / Pulmonary Embolism / Terminal Care / Thrombosis / Biliary Tract / Biliary Tract Neoplasms / Blood Cell Count / Biomarkers / Retrospective Studies / Risk Factors Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male Language: Ko Journal: Korean Journal of Medicine Year: 2018 Type: Article
Full text: 1 Index: WPRIM Main subject: Pancreatic Neoplasms / Pulmonary Embolism / Terminal Care / Thrombosis / Biliary Tract / Biliary Tract Neoplasms / Blood Cell Count / Biomarkers / Retrospective Studies / Risk Factors Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Female / Humans / Male Language: Ko Journal: Korean Journal of Medicine Year: 2018 Type: Article