Proposal of a Pretreatment Nomogram for Predicting Local Recurrence after Intensity-Modulated Radiation Therapy in T4 Nasopharyngeal Carcinoma: A Retrospective Review of 415 Chinese Patients / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 1084-1095, 2018.
Article
in English
| WPRIM
| ID: wpr-717455
ABSTRACT
PURPOSE:
Local relapse-free survival (LRFS) differs widely among patients with T4 category nasopharyngeal carcinoma (NPC). We aimed to build a nomogram incorporating clinicopathological information to predict LRFS in T4 NPC after definitive intensity-modulated radiation therapy (IMRT). MATERIALS ANDMETHODS:
Retrospective study of 415 Chinese patients with non-metastatic T4 NPC treated with definitive IMRT with or without chemotherapy at our cancer center between October 2009 and September 2013. The nomogram for LRFS at 3 and 5 years was generated based on multivariate Cox proportional hazards regression, and validated using bootstrap resampling, assessing discriminative performance using the concordance index (C-index) and determining calibration ability via calibration curves.RESULTS:
Five-year LRFS was 88.8%. We identified and incorporated four independent prognostic factors for LRFS ethmoid sinus invasion, primary gross tumor volume, age, and pretreatment body mass index. The C-index of the nomogram for local recurrence was 0.732 (95% confidence interval, 0.726 to 0.738), indicating excellent predictive accuracy. The calibration curve revealed excellent agreement between nomogram-predicted and observed LRFS probabilities. Risk subgroups based on total point score cutoff values enabled effective discrimination of LRFS.CONCLUSION:
This pretreatment nomogram enables clinicians to accurately predict LRFS in T4 NPC after definitive IMRT, and could help to facilitate personalized patient counselling and treatment strategies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Calibration
/
Body Mass Index
/
Retrospective Studies
/
Asian People
/
Tumor Burden
/
Nomograms
/
Discrimination, Psychological
/
Drug Therapy
/
Ethmoid Sinus
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Cancer Research and Treatment
Year:
2018
Type:
Article
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