The NEAT Predictive Model for Survival in Patients with Advanced Cancer / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 1433-1443, 2018.
Article
in English
| WPRIM
| ID: wpr-717511
ABSTRACT
PURPOSE:
We previously developed a model to more accurately predict life expectancy for stage IV cancer patients referred to radiation oncology. The goals of this study are to validate this model and to compare competing published models. MATERIALS ANDMETHODS:
From May 2012 to March 2015, 280 consecutive patientswith stage IV cancerwere prospectively evaluated by a single radiation oncologist. Patients were separated into training, validation and combined sets. TheNEAT model evaluated number of active tumors (“N”), Eastern Cooperative Oncology Group performance status (“E”), albumin (“A”) and primary tumor site (“T”). The Odette Cancer Center model validated performance status, bone only metastases and primary tumor site. The Harvard TEACHH model investigated primary tumor type, performance status, age, prior chemotherapy courses, liver metastases, and hospitalization within 3 months. Cox multivariable analyses and logisticalregressionwere utilized to compare model performance.RESULTS:
Number of active tumors, performance status, albumin, primary tumor site, prior hospitalizationwithin the last 3 months, and liver metastases predicted overall survival on uinvariate and multivariable analysis (p < 0.05 for all). The NEAT model separated patients into four prognostic groups with median survivals of 24.9, 14.8, 4.0, and 1.2 months, respectively (p < 0.001). The NEAT model had a C-index of 0.76 with a Nagelkerke’s R2 of 0.54 suggesting good discrimination, calibration and total performance compared to competing prognostic models.CONCLUSION:
The NEAT model warrants further investigation as a clinically useful approach to predict survival in patients with stage IV cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Calibration
/
Prospective Studies
/
Life Expectancy
/
Radiation Oncology
/
Discrimination, Psychological
/
Drug Therapy
/
Hospitalization
/
Liver
/
Neoplasm Metastasis
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Cancer Research and Treatment
Year:
2018
Type:
Article
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