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Lifestyle Risk Prediction Model for Prostate Cancer in a Korean Population / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment ; : 1194-1202, 2018.
Article in English | WPRIM | ID: wpr-717748
ABSTRACT

PURPOSE:

The use of prostate-specific antigen as a biomarker for prostate cancer (PC) has been controversial and is, therefore, not used by many countries in their national health screening programs. The biological characteristics of PC in East Asians including Koreans and Japanese are different from those in the Western populations. Potential lifestyle risk factors for PC were evaluated with the aim of developing a risk prediction model. MATERIALS AND

METHODS:

A total of 1,179,172 Korean men who were cancer free from 1996 to 1997, had taken a physical examination, and completed a lifestyle questionnaire, were enrolled in our study to predict their risk for PC for the next eight years, using the Cox proportional hazards model. The model’s performance was evaluated using the C-statistic and Hosmer–Lemeshow type chi-square statistics.

RESULTS:

The risk prediction model studied age, height, body mass index, glucose levels, family history of cancer, the frequency of meat consumption, alcohol consumption, smoking status, and physical activity, which were all significant risk factors in a univariate analysis. The model performed very well (C statistic, 0.887; 95% confidence interval, 0.879 to 0.895) and estimated an elevated PC risk in patients who did not consume alcohol or smoke, compared to heavy alcohol consumers (hazard ratio [HR], 0.78) and current smokers (HR, 0.73) (p < 0.001).

CONCLUSION:

This model can be used for identifying Korean and other East Asian men who are at a high risk for developing PC, as well as for cancer screening and developing preventive health strategies.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Physical Examination / Prostate / Prostatic Neoplasms / Smoke / Population Characteristics / Body Height / Alcohol Drinking / Smoking / Proportional Hazards Models / Mass Screening Type of study: Diagnostic study / Etiology study / Prognostic study / Risk factors / Screening study Limits: Humans / Male Language: English Journal: Cancer Research and Treatment Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Physical Examination / Prostate / Prostatic Neoplasms / Smoke / Population Characteristics / Body Height / Alcohol Drinking / Smoking / Proportional Hazards Models / Mass Screening Type of study: Diagnostic study / Etiology study / Prognostic study / Risk factors / Screening study Limits: Humans / Male Language: English Journal: Cancer Research and Treatment Year: 2018 Type: Article