Prognostic Factors and Decision Tree for Long-Term Survival in Metastatic Uveal Melanoma / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 1130-1139, 2018.
Article
in English
| WPRIM
| ID: wpr-717754
ABSTRACT
PURPOSE:
The purpose of this study was to demonstrate the existence of a bimodal survival pattern in metastatic uveal melanoma. Secondary aims were to identify the characteristics and prognostic factors associated with long-term survival and to develop a clinical decision tree. MATERIALS ANDMETHODS:
The medical records of 99 metastatic uveal melanoma patients were retrospectively reviewed. Patients were classified as either short (≤ 12 months) or long-term survivors (> 12 months) based on a graphical interpretation of the survival curve after diagnosis of the first metastatic lesion. Ophthalmic and oncological characteristicswere assessed in both groups.RESULTS:
Of the 99 patients, 62 (62.6%) were classified as short-term survivors, and 37 (37.4%) as long-term survivors. The multivariate analysis identified the following predictors of long-term survival age ≤ 65 years (p=0.012) and unaltered serum lactate dehydrogenase levels (p=0.018); additionally, the size (smaller vs. larger) of the largest liver metastasis showed a trend towards significance (p=0.063). Based on the variables significantly associated with long-term survival, we developed a decision tree to facilitate clinical decision-making.CONCLUSION:
The findings of this study demonstrate the existence of a bimodal survival pattern in patients with metastatic uveal melanoma. The presence of certain clinical characteristics at diagnosis of distant disease is associated with long-term survival. A decision tree was developed to facilitate clinical decision-making and to counsel patients about the expected course of disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Decision Trees
/
Medical Records
/
Multivariate Analysis
/
Retrospective Studies
/
Survivors
/
Diagnosis
/
Clinical Decision-Making
/
L-Lactate Dehydrogenase
/
Liver
/
Melanoma
Type of study:
Diagnostic study
/
Health economic evaluation
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Cancer Research and Treatment
Year:
2018
Type:
Article
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