Endoscopic Findings of Children with Familial Mediterranean Fever / 대한소아소화기영양학회지
Pediatric Gastroenterology, Hepatology & Nutrition
;
: 271-277, 2018.
Article
in English
| WPRIM
| ID: wpr-717810
ABSTRACT
PURPOSE:
Familial Mediterranean fever (FMF) is an auto inflammatory disease characterized by periodic fever, synovitis and serositis. Patients may be admitted to gastroenterology units due to gastrointestinal symptoms. In this study; we aimed to analyze endoscopic findings and diagnostic utility of endoscopic procedure in children with FMF.METHODS:
Patient with FMF that was performed endoscopy for the gastrointestinal symptoms were included to the study (39 of 164 patients, 53 procedure). A control group was randomly designed as age and gender matched four endoscopic procedures per one endoscopic procedure of patients with FMF (n=212).RESULTS:
No different was found between the patients and control group in esophagogastroscopy findings. However, the diagnosis of gastrointestinal pathology was made by esophagogastroscopy in 46.2% patients. Colonoscopic examination revealed that the frequency of inflammatory bowel disease (IBD) was higher in undiagnosed patients compared to both the control group (50.0% vs. 6.9%, p < 0.05, odds ratio [OR]13.4 and 95% confidence inteval [95% CI] 2.1–84.3) and the patients under colchicine treatment (50.0% vs. 8.3%, p < 0.05, OR 11 and 95% CI 0.8–147.8). Colonoscopic procedure that was made after the diagnosis was found to provide contribution by 16.7% in determining the etiology of the additional symptoms.CONCLUSION:
Patients with FMF may be admitted to pediatric gastroenterology outpatient clinic prior to diagnosis or during the follow-up period. The frequency of IBD is high in undiagnosed patients with FMF. Endoscopic procedures may be helpful in these patients for the diagnosis accompanying mucosal lesions.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Familial Mediterranean Fever
/
Serositis
/
Synovitis
/
Inflammatory Bowel Diseases
/
Odds Ratio
/
Colchicine
/
Follow-Up Studies
/
Colonoscopy
/
Gastroscopy
Type of study:
Diagnostic study
/
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Child
/
Humans
Language:
English
Journal:
Pediatric Gastroenterology, Hepatology & Nutrition
Year:
2018
Type:
Article
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