Effects of 5HT1A Activation on Depression Profile Following 5-HT Depletion in Rats Lacking Social Attachment Since Weanling
Psychiatry Investigation
;
: 1000-1006, 2018.
Article
in English
| WPRIM
| ID: wpr-717817
ABSTRACT
OBJECTIVE:
Post weanling isolation-reared (IR) rats are featured with depressive phenotype, yet its mechanism is not clearly defined particularly in terms of the involvement of central 5-HT1A receptors. The present study aims to examine the effects of 5HT1A activation on forced swim test (FST) in IR rats following 5-HT depletion.METHODS:
Social control (SOC) and IR rats received an intracerebraoventricular (ICV) injection of 5-HT depletion agent, 5,7-DHT. 14 days after the surgery, rats were assessed their performance in FST with or without the challenge with a 5-HT1A agonist, 8-OH-DPAT. Rats were then sacrificed for analyzing their 5-HT tissue levels and the expressions of their 5-HA1A receptors in prefrontal cortex (PFC), hippocampus (HPX), and amygdala (AMY).RESULTS:
5,7-DHT decreased the tissue concentration of 5-HT in both IR and SOC rats. IR rats were more immobile and less sensitive to the lesion-induced immobility, however this effect was reversed by acute challenge of 8-OH-DPAT. 5,7-DHT lesion increased the expression of PFC 5-HT1A receptors.CONCLUSION:
The integrity of central 5-HT system is developmentally crucial for the 5-HT1A-relevant depression profile in rats of social isolation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Social Control, Formal
/
Social Isolation
/
Serotonin
/
8-Hydroxy-2-(di-n-propylamino)tetralin
/
Prefrontal Cortex
/
Receptor, Serotonin, 5-HT1A
/
Depression
/
Serotonin 5-HT1 Receptor Agonists
/
Hippocampus
Limits:
Animals
Language:
English
Journal:
Psychiatry Investigation
Year:
2018
Type:
Article
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