Longevity and Stress Resistant Property of 6-Gingerol from Zingiber officinale Roscoe in Caenorhabditis elegans
Biomolecules & Therapeutics
;
: 568-575, 2018.
Article
in English
| WPRIM
| ID: wpr-717996
ABSTRACT
In order to discover lifespan-extending compounds made from natural resources, activity-guided fractionation of Zingiber officinale Roscoe (Zingiberaceae) ethanol extract was performed using the Caenorhabditis elegans (C. elegans) model system. The compound 6-gingerol was isolated from the most active ethyl acetate soluble fraction, and showed potent longevity-promoting activity. It also elevated the survival rate of worms against stressful environment including thermal, osmotic, and oxidative conditions. Additionally, 6-gingerol elevated the antioxidant enzyme activities of C. elegans, and showed a dose-depend reduction of intracellular reactive oxygen species (ROS) accumulation in worms. Further studies demonstrated that the increased stress tolerance of 6-gingerol-mediated worms could result from the promotion of stress resistance proteins such as heat shock protein (HSP-16.2) and superoxide dismutase (SOD-3). The lipofuscin levels in 6-gingerol treated intestinal worms were decreased in comparison to the control group. No significant 6-gingerol-related changes, including growth, food intake, reproduction, and movement were noted. These results suggest that 6-gingerol exerted longevity-promoting activities independently of these factors and could extend the human lifespan.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reproduction
/
Superoxide Dismutase
/
Caenorhabditis
/
Survival Rate
/
Reactive Oxygen Species
/
Caenorhabditis elegans
/
Natural Resources
/
Ginger
/
Ethanol
/
Eating
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Biomolecules & Therapeutics
Year:
2018
Type:
Article
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