Bioactive Compounds for the Treatment of Renal Disease
Yonsei Medical Journal
;
: 1015-1025, 2018.
Article
in English
| WPRIM
| ID: wpr-718040
ABSTRACT
Kidney diseases including acute kidney injury and chronic kidney disease are among the largest health issues worldwide. Dialysis and kidney transplantation can replace a significant portion of renal function, however these treatments still have limitations. To overcome these shortcomings, a variety of innovative efforts have been introduced, including cell-based therapies. During the past decades, advances have been made in the stem cell and developmental biology, and tissue engineering. As part of such efforts, studies on renal cell therapy and artificial kidney developments have been conducted, and multiple therapeutic interventions have shown promise in the pre-clinical and clinical settings. More recently, therapeutic cell-secreting secretomes have emerged as a potential alternative to cell-based approaches. This approach involves the use of renotropic factors, such as growth factors and cytokines, that are produced by cells and these factors have shown effectiveness in facilitating kidney function recovery. This review focuses on the renotropic functions of bioactive compounds that provide protective and regenerative effects for kidney tissue repair, based on the available data in the literature.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stem Cells
/
Developmental Biology
/
Cytokines
/
Kidney Transplantation
/
Recovery of Function
/
Tissue Engineering
/
Intercellular Signaling Peptides and Proteins
/
Regenerative Medicine
/
Dialysis
/
Renal Insufficiency
Language:
English
Journal:
Yonsei Medical Journal
Year:
2018
Type:
Article
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