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The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis
Experimental & Molecular Medicine ; : e40-2013.
Article in English | WPRIM | ID: wpr-71809
ABSTRACT
In this study, we examined the therapeutic effects of an immune-stimulating peptide, WKYMVm, in ulcerative colitis. The administration of WKYMVm to dextran sodium sulfate (DSS)-treated mice reversed decreases in body weight, bleeding score and stool score in addition to reversing DSS-induced mucosa destruction and shortened colon. The WKYMVm-induced therapeutic effect against ulcerative colitis was strongly inhibited by a formyl peptide receptor (FPR) 2 antagonist, WRWWWW, indicating the crucial role of FPR2 in this effect. Mechanistically, WKYMVm effectively decreases intestinal permeability by stimulating colon epithelial cell proliferation. WKYMVm also strongly decreases interleukin-23 and transforming growth factor-beta production in the colon of DSS-treated mice. We suggest that the potent immune-modulating peptide WKYMVm and its receptor FPR2 may be useful in the development of efficient therapeutic agents against chronic intestinal inflammatory diseases.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Oligopeptides / Permeability / Colitis, Ulcerative / Adjuvants, Immunologic / Transforming Growth Factor beta / Colon / Caco-2 Cells / Receptors, Formyl Peptide / Cell Proliferation / Interleukin-23 Limits: Animals / Humans Language: English Journal: Experimental & Molecular Medicine Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Oligopeptides / Permeability / Colitis, Ulcerative / Adjuvants, Immunologic / Transforming Growth Factor beta / Colon / Caco-2 Cells / Receptors, Formyl Peptide / Cell Proliferation / Interleukin-23 Limits: Animals / Humans Language: English Journal: Experimental & Molecular Medicine Year: 2013 Type: Article