Anti-Tumor Necrosis Factor Therapy in Intestinal Behçet's Disease
Gut and Liver
;
: 623-632, 2018.
Article
in English
| WPRIM
| ID: wpr-718125
ABSTRACT
Intestinal Behçet's disease is a rare, immune-mediated chronic intestinal inflammatory disease; therefore, clinical trials to optimize the management and treatment of patients are scarce. Moreover, intestinal Behçet's disease is difficult to treat and often requires surgery because of the failure of conventional medical treatment. Administration of anti-tumor necrosis factor–α, a potential therapeutic strategy, is currently under active clinical investigation, and evidence of its effectiveness for both intestinal Behçet's disease and inflammatory bowel diseases has been accumulating. Here, we review updated data on current experiences and outcomes after the administration of anti-tumor necrosis factor–α for the treatment of intestinal Behçet's disease. In addition to infliximab and adalimumab, which are the most commonly used agents, we describe agents such as golimumab, etanercept, and certolizumab pegol, which have recently been shown to be effective in refractory intestinal Behçet's disease. This review also discusses safety issues associated with anti-tumor necrosis factor–α, including vulnerability to infections and malignancy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Inflammatory Bowel Diseases
/
Behcet Syndrome
/
Certolizumab Pegol
/
Adalimumab
/
Infliximab
/
Etanercept
/
Necrosis
Limits:
Humans
Language:
English
Journal:
Gut and Liver
Year:
2018
Type:
Article
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