A Case of Thyrotoxic Myopathy with Extreme Type 2 Fiber Predominance
Experimental Neurobiology
;
: 232-234, 2013.
Article
in English
| WPRIM
| ID: wpr-71814
ABSTRACT
In hyperthyroidism, many patients had neuromuscular symptoms and clinical weakness correlated with free thyroxine (T4) concentrations. The common clinical symptoms of chronic thyrotoxic myopathy were characterized by progressive weakness in proximal muscles and atrophy. A 55-year old woman was visited our hospital with two years of progressive weakness of both legs. Physical examination showed diffuse enlargement of the thyroid gland, muscle atrophy and tachycardia. Motor examination showed proximal weakness in both legs. Serum creatine phosphokinase was normal and electromyography showed a myopathic pattern. Serum thyroxine (T4) was greatly increased and serum thyroid stimulating hormone was very low. Muscle biopsy showed mild atrophic change and type 2 fiber predominance. The patient's symptoms were improved during treatment with methimazole. Herein we report a case of thyrotoxic myopathy with extreme type 2 fiber predominance histologically.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physical Examination
/
Atrophy
/
Tachycardia
/
Thyroid Gland
/
Thyroxine
/
Biopsy
/
Thyrotropin
/
Muscular Atrophy
/
Creatine Kinase
/
Electromyography
Limits:
Female
/
Humans
Language:
English
Journal:
Experimental Neurobiology
Year:
2013
Type:
Article
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