Clozapine-related Sudden Pericarditis in a Patient Taking Long Acting Aripiprazole and Valproate: A Case Report
Clinical Psychopharmacology and Neuroscience
;
: 505-507, 2018.
Article
in English
| WPRIM
| ID: wpr-718208
ABSTRACT
Clozapine may be associated with cardiovascular adverse effects including QTc prolongation and, more rarely, with myocarditis and pericarditis. Although rare, these latter cardiovascular adverse effects may be life-threatening and must be immediately recognized and treated. Several cases of clozapine related-pericarditis have been described and often it has a subtle and insidious onset with symptoms that may be often misdiagnosed with psychiatric manifestations (e.g. anxiety, panic or somatization) leading to a delayed correct diagnosis with potential fatal consequences. In the present report we describe the case of a 27-year-old girl with schizoaffective disorder taking long acting aripiprazole and valproate who developed a sudden onset clozapine-related pericarditis during titration phase that resolved with immediate clozapine discontinuation and indomethacin administration. We underline the importance of an early diagnosis of clozapine-related pericarditis and the need to have monitoring protocols to prevent this potentially fatal adverse effect especially when polypharmacy is administered to patients taking clozapine.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Anxiety
/
Panic
/
Pericarditis
/
Psychotic Disorders
/
Indomethacin
/
Valproic Acid
/
Drug Monitoring
/
Clozapine
/
Polypharmacy
/
Early Diagnosis
Type of study:
Diagnostic study
/
Practice guideline
/
Screening study
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Clinical Psychopharmacology and Neuroscience
Year:
2018
Type:
Article
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