Presence of Sarcopenia and Its Rate of Change Are Independently Associated with Long-term Mortality in Patients with Liver Cirrhosis
Journal of Korean Medical Science
;
: e299-2018.
Article
in English
| WPRIM
| ID: wpr-718407
ABSTRACT
BACKGROUND:
Sarcopenia is associated with a poor prognosis in patients with liver cirrhosis. However, it is not known whether the rate of skeletal muscle depletion is also associated with a poor prognosis. We investigated the prognostic impact of the rate of skeletal muscle depletion in patients with liver cirrhosis.METHODS:
We included retrospectively all patients with liver cirrhosis who underwent both multiple computed tomography scans and hepatic venous pressure gradient (HVPG) measurements.RESULTS:
A total of 131 patients with liver cirrhosis were enrolled. The mean age of the patients was 53.7 years and alcoholic liver disease was the most common cause (61.8%). Sixty-four patients (48.9%) were diagnosed with sarcopenia. The median changes in skeletal muscle area per year (ΔSMA/y) were −0.89%. During a median follow-up period of 46.2 months (range, 3.4–87.6), 45 patients (34.4%) died. In multivariate analyses, age, Child-Pugh score, HVPG, presence of sarcopenia and ΔSMA/y were independently associated with mortality. Cumulative mortality was significantly higher in patients with ΔSMA/y <−2.4% than those with ΔSMA/y ≥−2.4% (log-rank test, P < 0.001).CONCLUSION:
Both the presence and rate of change of sarcopenia are independently associated with long-term mortality in patients with liver cirrhosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Venous Pressure
/
Multivariate Analysis
/
Retrospective Studies
/
Follow-Up Studies
/
Mortality
/
Muscle, Skeletal
/
Sarcopenia
/
Liver
/
Liver Cirrhosis
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS